ABSTRACT
Objective To evaluate the significance of HE4 ,CA125 and ROMA indexes in the diagnosis of ovarian cancer in different menopausal status women .Methods After the gynecological mass was taken for pathological diagnosis ,a total of 73 cases of ovarian cancer (ovarian cancer group ,divided into early stage and late stage) and 66 cases of gynecological benign tumor (benign tumor group ) were selected .57 healthy women were selected as controls (control group ) . All groups were further divided into non-menopausal and postmenopausal groups .Serum levels of HE4 and CA125 were measured by chemiluminescence immunoassay and the ROMA index was calculated . Results ① The serum levels of HE4 , CA125 and ROMA in ovarian cancer group were significantly higher than those in benign tumor group and healthy control group (P<0 .01) .② When benign tumor group and control group were taken as a reference , the receiver operating characteristic (ROC ) curve analysis showed that the area under the curve (AUC) of HE4 ,CA125 and ROMA in the non-menopausal group and the postmenopausal group was (0 .944 ,0 .822 ,0 .941 vs .0 .994 ,1 .000 ,1 .000) ,respectively .③ In non-menopausal group ,HE4 has higher specificity and positive predictive value .The best cut off value was 75 .92 pmol/mL ,the diagnostic sensitivity and specificity were 73 .1% and 100% .In postmenopausal group ,CA125 has higher sensitivity , the optimum cut off value was 57 .65 U/mL ,the diagnostic sensitivity and specificity were 100% and 95 .4% .④ In the postmenopausal group ,there was no significant difference in serum CA 125 level between the early and late ovarian cancer patients (P> 0 .05) .Conclusion In the premenopausal group HE4 has a better differential diagnostic value .In postmenopausal group ,the ROMA index could give consideration to both sensitivity and specificity ,and had higher diagnostic efficacy .It plays roles in the diagnosis of ovarian cancer to establish the appropriate reference interval of HE4 ,CA125 and ROMA indexes according to the different menopausal status .